Children with poor nutrition who are receiving broad spectrum antibiotics.Ĥ. Children with disorders that interfere with absorption of vitamin K (chronic diarrhoea, cystic fibrosis, biliary atresia, hepatitis, coeliac disease).Ģ. Likely indications for using vitamin K in children are limited and may include:ġ. It is advisable that a haematologist is consulted about appropriate investigation and treatment in any child in whom Konakion MM/Phytomenadione 10 mg/1 ml is being considered.
Konakion MM/Phytomenadione 10 mg/1 ml solution should not be diluted or mixed with other injectables, but may be injected into the lower part of an infusion apparatus.
The solution should be freshly prepared and protected from light. This medicine is for intravenous injection and should be diluted with 55 ml of 5% glucose before slowly infusing the product. The dosage for this patient group should therefore be at the lower end of the ranges recommended. The half-lives of these anticoagulants are different to warfarin and different doses of vitamin K 1 may be required.Įlderly patients tend to be more sensitive to reversal of anticoagulation with Konakion MM/Phytomenadione 10 mg/1 ml. There are limited data regarding reversal of the effects of other anticoagulants, such as acenocoumarol or phenprocoumon. The dosing recommendations above apply to patients taking warfarin. Use with anticoagulants other than warfarin If surgery cannot be delayed, PCC can be given in addition to intravenous vitamin K 1 and the INR checked before surgery. Patients who require emergency surgery that can be delayed for 6-12 hours can be given 5 mg intravenous vitamin K 1 to reverse the anticoagulant effect. Reversal of anticoagulation prior to surgery For small doses one or more ampoules of Konakion MM Paediatric/ Phytomenadione 2 mg/0.2 ml solution for injection (same solution) can be used.